As an important chemical product and raw material of chemical synthesis drugs, pharmaceutical intermediates have great production value and are an important part of fine chemical industry.
There is a great upgrading of pharmaceutical intermediates. The development direction of Chinese pharmaceutical intermediates is mainly the new research and development of pharmaceutical intermediates or the use of new production processes, so as to enhance the ability of independent research and innovation of enterprises.
▲ The development and production of pharmaceutical intermediates are included in the chemical technology services of some companies.
In recent years, the world medical intermediate production technology has been greatly developed, including combinatorial chemistry, biocatalyzation, cellular biochemistry, chiral chemistry, peptide synthesis, carbohydrate synthesis and other new technologies, make the intermediate production efficiency is higher, more friendly to the environment.
Common types of pharmaceutical intermediates
01. vitamin intermediates
For example, sorbitol for the production of vitamin C, isophytol for vitamin E and β-ionone for the synthesis of vitamin E and vitamin A, an important intermediate, the market demand is large and the prospect is broad.
02. Heterocyclic compounds
Widely used in medicine, pesticides and veterinary drugs and intermediates, most of the mother (nuclear). For example, the treatment of hypertension cosoya (losartan potassium tablets), oxoxi (amlodipine) are heterocyclic compounds; The main heterocyclic compounds are imidazole, thiazole, triazole, pyridine, pyrimidine, piperazine and triazine and some of their derivatives.
03. Fluorinated compounds
Introduction of new elements into pharmaceutical intermediates for improvement, the most successful application being fluorine. At present, there are hundreds of fluorine-containing drugs at home and abroad, and many of them have become the main varieties for the treatment of some diseases. Fluorine-containing drugs have the characteristics of small dosage, low toxicity, high efficacy and strong metabolic capacity, and have a pivotal position in the pharmaceutical field.
04. Chiral compounds
A compound obtained by asymmetric synthesis or resolution based on stereochemistry. Chiral compounds have a wide range of uses and are important organic compounds.
With the development of biotechnology, people will use microbial pathway to develop new chiral products to separate special enzymes and microbial strains, which can be used to produce various chiral amines, chiral amino acids and other chiral intermediate products.
In order to shorten the cycle of new drug research and development, reduce the cost of new drug research and development, and improve the rate of capital turnover, intermediates are generally outsourced and customized production.
We provide chemical technology services. We have rich experience in optimizing the process of intermediates and apis and developing new, safe and environmentally friendly process routes. We are committed to developing stable and low-cost processes suitable for mass production for our customers.
05. Biological compounds
The application of DNA recombination technology, cell engineering technology and enzyme engineering technology to the treatment of cardiovascular diseases, diabetes, hepatitis, tumor, anti-aging and other medicines, and the application of modern biotechnology to transform the traditional pharmaceutical industry.
Pharmaceutical intermediate process research and development technology
The research and development and production of pharmaceutical intermediates is an industry with many barriers, and is by no means a “processing plant without technical content”.
R&d and production enterprises need to provide the following technologies:
- Directional nitrification technology
Adopt neutral acid nitrification (clean nitrification) to reduce costs, eliminate pollution and achieve the level of green nitrification.
High temperature and high pressure reaction technology
Reducing the reaction volume, reagent cost and drug waste production, the equipment can be used to complete condensation, polymerization, hydrocarbon, hydrogenation and other chemical processes. - Condensation technology
By mannich condensation, Aldol condensation of aldehydes and ketones to obtain macromolecules, the choice of catalyst is a key technology. - Control oxidation technology
It is easy for lipid aromatic group to oxidize into acid, and its intermediate aromatic aldehydes are important intermediates in medicine and pesticides. - Fluorination technology
Introduction of fluoride into organic intermediates, synthetic fluoride is an important medical intermediate, how to introduce fluorine into the mother is the object of concern. - Hydrogenation reduction technology
Reduction technologies such as iron powder reduction and sodium sulfur reduction are seriously polluted. The selection and application of catalysts are the key to the success of hydrogenation reduction.
Post time: Nov-12-2022